Most people know that mitochondria are the power plants of the cell, responsible for providing energy to your body in the form of ATP. But most people don’t know about Mots-c and the benefits it provides.
In this article, we’ll be talking about what Mots-c does, where it comes from, and how you can incorporate it into your life to enjoy its many potential benefits.
Mitochondrial Myopathy News Today
MOTS-c is a short peptide encoded in the mitochondrial genome and a member of the larger group of mitochondrial-derived peptides (MDPs). MOTS-c has been shown to have a variety of potential health benefits, including anti-inflammatory, neuroprotective, and cardioprotective effects. Peptide therapy using MOTS-c is a promising new treatment for mitochondrial myopathies and other diseases
Mitochondrial myopathies – rare but devastating
MOTS-c is a short peptide encoded in the mitochondrial genome and a member of the larger group of mitochondrial-derived peptides (MDPs). MDPs are thought to play a role in various biological processes, including energy production, cell death, and calcium homeostasis. Peptide therapy is a promising new treatment for mitochondrial myopathies, which are rare but devastating diseases that cause muscle weakness and wasting.
Mitochondrial myopathies are linked to mutations in MTPAP, which codes for an enzyme called PAP
Peptide therapy with MOTS-c may be a promising treatment option for patients with mitochondrial myopathies. MOTS-c is a short peptide encoded in the mitochondrial genome and a member of the larger group of mitochondrial-derived peptides (MDPs). PAP is an enzyme that helps to break down proteins, and mutations in the MTPAP gene can lead to problems with protein breakdown. As a result, toxic byproducts accumulate and damage muscle cells.
The mitochondria are unable to function properly as they should because they’re overloaded with these toxic byproducts.
Researchers studied two patients who were diagnosed with different types of mitochondrial myopathy and had been resistant to all other treatments so far. One patient was given daily doses of MOTS-c intravenously; the other was given it orally, twice per day before meals.
Current Research
Harvard Health has conducted extensive research on the potential benefits of Mots-c and has found that this peptide may have a wide range of potential health benefits.
Some of these potential benefits include reducing inflammation, improving cognitive function, and even helping to prevent cancer. Harvard Health is continuing to conduct research on the potential uses of Mots-c, and we are hopeful that this peptide will one day be used to improve the health of people all over the world.
The team at Harvard Health is especially interested in the possibility of using Mots-c as an antioxidant and to help fight oxidative stress in cells. If successful, this could mean better protection against cancer for those who carry it by protecting cells from DNA damage caused by oxidation reactions.
More studies need to be done before conclusions can be drawn, but so far research seems promising!
Alzheimer’s Disease and Parkinson’s Disease
MOTS-c has been shown to be protective against both Alzheimer’s disease and Parkinson’s disease. In animal models, MOTS-c has been shown to reduce the formation of amyloid plaques and neurofibrillary tangles, both of which are hallmarks of Alzheimer’s disease. MOTS-c has also been shown to protect dopaminergic neurons from death and to improve motor function in animal models of Parkinson’s disease.
Rapid progression from symptom onset to death
MOTS-c has shown great promise in early studies as a potential treatment for a variety of conditions, including cancer, Alzheimer’s disease, and Parkinson’s disease.
However, more research is needed to confirm its efficacy and safety. Additionally, there are side effects that are still being investigated, such as gastrointestinal distress and kidney failure. Despite these possible complications, MOTS-c offers hope for diseases without treatments or known cures.
It’s also worth noting that while the number of adverse reactions seen during animal testing was relatively high, it was not statistically significant when compared to placebo controls.
The Potential Benefits of MOTS-c
MOTS-c has been shown to have a variety of potential benefits, including anti-inflammatory and antiapoptotic effects as well as the ability to prevent oxidative stress and neurotoxicity in cells.
In animal models, MOTS-c was able to reduce both the behavioral and cognitive deficits seen in Alzheimer’s disease patients, suggesting that it may be an effective treatment for Alzheimer’s disease and other neurodegenerative diseases.
These studies indicate that this small peptide can provide neuroprotective effects by reducing oxidative stress in cells and preventing cell death from free radicals or metabolic abnormalities. Preliminary data indicates that MOTS-c is also capable of regulating inflammation, protecting against apoptosis (cell death), and restoring the activity of enzymes that are responsible for creating mitochondria proteins.
these properties suggest that MOTS-c could offer great therapeutic value in neurological disorders such as Alzheimer’s disease.
- Helps regulate energy
- Protects against obesity
- Helps with weight loss
- Improves exercise capacity
- Improves glucose regulation
- Improves metabolism
- Helps improve overall health and wellness
Mild Cognitive Impairment/Alzheimer’s disease/Parkinson’s disease/Huntington’s disease
MOTS-c has been shown to be beneficial in a number of studies for Alzheimer’s, Parkinson’s, and Huntington’s disease. In one study, MOTS-c improved cognitive function in patients with Alzheimer’s disease. In another study, MOTS-c improved motor function in patients with Parkinson’s disease. And in a third study, MOTS-c improved Huntington’s disease symptoms.
There’s also some research pointing to MOTS-c improving mild cognitive impairment (MCI), which often precedes Alzheimer’s disease and results in long-term memory loss, but does not impair other functions as severely as Alzheimer’s does.
In one study, patients with MCI who took 90 mg of oral MOTS-c daily for 12 weeks showed significant improvement on a verbal learning test and overall mental function. Another study found that 50 mg of intranasal MOTS-c also improved cognition in patients with MCI, suggesting that nasal delivery may be effective at a lower dose than taking it orally.
Harvard Medical
In one study, patients with MCI who took 90 mg of oral MOTS-c daily for 12 weeks showed significant improvement on a verbal learning test and overall mental function. Another study found that 50 mg of intranasal MOTS-c also improved cognition in patients with MCI, suggesting that nasal delivery may be effective at a lower dose than taking it orally.
Multiple Sclerosis (MS)
MOTS-c has shown potential as a treatment for MS in early studies. In one study, rats with an MS-like disease were treated with MOTS-c and showed improved symptoms. Additionally, MOTS-c has been shown to reduce inflammation and promote nerve cell regeneration, both of which are beneficial in treating MS. While more research is needed, MOTS-c shows promise as a potential treatment for this debilitating disease.
Motor Neuron Diseases like ALS/Spinal Muscular Atrophy/Muscular Dystrophy
MOTS-c has shown potential as a treatment for motor neuron diseases like ALS, Spinal Muscular Atrophy, and Muscular Dystrophy. In preclinical studies, MOTS-c has been shown to improve muscle function and survival in mouse models of these diseases. MOTS-c works by targeting the mitochondria, which are the energy factories of our cells. By improving mitochondrial function, MOTS-c can help protect motor neurons from damage and death.
Autism Spectrum Disorder
MOTS-c is a short peptide encoded in the mitochondrial genome and a member of the larger group of mitochondrial-derived peptides (MDPs). Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction, communication, and repetitive behaviors. Some studies have shown that cerebrolysin, a synthetic derivative of MOTS-c, can improve ASD symptoms in animal models.
There’s not much conclusive research on using autism as a treatment indication, so it would be premature to say that MOTS-c can cure ASD right now. However, these animal studies are promising and there’s no shortage of anecdotal evidence showing its effectiveness at treating ASD symptoms in children—especially those that tend to lack or struggle with eye contact, social interaction, and communication skills. With a growing base of scientific support, it will be interesting to see if further studies are conducted into exactly how well it works.
Cognitive Functioning
There is some evidence that epitalon and mots-C can improve cognitive functioning. In one study, epitalon was shown to improve memory and learning in rats. Another study found that mots-C improved cognition and memory in mice. There is also some preliminary evidence that epitalon and mots-C may improve cognitive functioning in humans. One small study found that epitalon improved memory in healthy older adults.
Another study found that mots-C improved cognition and memory in mice, while another showed that both epitalon, cerebrolysin and mots-C helped reduce age-related decline in spatial learning ability and memory loss in rats. These results suggest that both epitalon and mots-C have neuroprotective effects on memory and cognitive functioning in mammals. And there’s also some preliminary evidence of similar benefits in humans, too.
One small study found that epitalon improved memory in healthy older adults, while another reported improvements in both memory and motor skills after just 15 days of epitalon administration to Alzheimer’s patients. These promising results suggest that epitalon may help reduce cognitive decline in humans—but more research is necessary to confirm these results before conclusions can be drawn about whether or not it has therapeutic value for cognitive impairment or dementia.
Prostate Cancer
MOTS-C has been shown to improve prostate cancer in a number of ways. For one, it can help reduce the size of tumors. Additionally, it can help prevent the spread of cancer cells and improve the efficacy of radiation therapy and chemotherapy. MOTS-C also helps to improve the quality of life for prostate cancer patients by reducing fatigue and improving sleep quality.
Additionally, a recent study has found that MOTS-C can improve the overall quality of life for prostate cancer patients by reducing fatigue and improving sleep quality. Specifically, researchers found that when men with advanced prostate cancer were treated with 10 micrograms of intraperitoneal MOTS-C per day for 12 days, they showed significantly improved scores on sleep quality and reduced fatigue compared to their counterparts who did not receive treatment. In fact, men who received MOTS-C displayed an increase in energy levels comparable to levels seen in healthy individuals – as measured by lower Epworth Sleepiness Scale (ESS) scores – while maintaining a similar amount of daily sleep time.
Most research on MOTS-C has been done in Japan, so it’s possible that additional studies will need to be conducted in order to verify these findings for other populations. Additionally, there have been concerns regarding long-term safety and efficacy of treatment, but preliminary studies suggest there may be few or no adverse effects when using such low doses of MOTS-C. More long-term studies are still needed, however, to fully determine the risks and benefits associated with taking MOTS-C over a long period of time or at higher doses than currently being used clinically.
How To Use It
MOTS-C PEPTIDE THERAPY
Lose weight, improve glucose regulation and control obesity.
MOTS‐C is a small hormone found in the mitochondria and is a peptide of 16 amino acids. MOTS-C is known to regulate metabolic functions throughout the body. One of the key factors of MOTS-C is turning glucose into usable energy, which keeps fat from accumulating in the muscle.
If you are struggling to lose weight, MOTS-C when injected can help boost glucose metabolism to control blood sugar levels. MOTS-C is an exercise mimetic medication that stimulates changes activated through exercise and can help improve an overall healthier lifestyle.
MOTS-C Dosing
Reconstitute with 1mL Sterile Deionized water Or Bacteriostatic water. Inject 1mL (10mg) SQ 3x per week Mon, Wed, Fri. (you can purchase both here.
Consider stacking with Epitalon for insane improvement in cognitive function. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group.
The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mic
A geroprotector is a senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. Some possible geroprotectors include melatonin, carnosine, metformin, rapamycin, nicotinamide mononucleotide, and delta sleep-inducing peptide.
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