What We’re Capable Of.
We took the price list down. A price list turns a physiological decision into a shopping decision — and that’s backwards. The Close Regenerative Index reads your biomarkers and decides exactly what your biology needs. We run the consultation, specify the protocol, and facilitate sourcing through independent ISO- and USP-certified partner facilities — then re-score you to prove it worked.
Consultations are complimentary and by application only. Acceptance is not guaranteed.
Source: Close Regenerative Index methodology. Full methodology & data provenance →
Minimal, laser-targeted, and able to show its work.
Most regenerative clinics sell you a menu and let you pick. We do the opposite: the biomarker data picks the single intervention most statistically likely to move your biology, at the lowest dose that clears the evidence bar — and we stop there. Nothing else is added until that variable is monitored, re-scored, and confirmed to be working.
That’s not conservatism for its own sake. It’s what two decades of physical medicine and regenerative practice, plus a decade of panel data, actually support: one primary variable at a time, complete monitoring, before complexity gets added. It also happens to be the only honest way to manage your budget — you are never paying for an intervention whose odds of working weren’t already priced into the decision.
Four steps. Every one of them measurable.
Data intake
Minimum 30 continuous days of wearable physiological data (HRV, sleep, ANS) or a recent blood panel. No data, no application review — this is the floor, not a formality.
Convergence scoring
Your biomarkers are synthesised across metabolic, inflammatory, hormonal, and cellular axes into a single composite score, benchmarked against a population dataset rather than a generic reference range.
Confidence-gated selection
Every candidate intervention carries a Bayesian confidence interval. Below the clinical action threshold, we don’t treat — we ask for more data instead. This is the step that keeps the plan minimal by design, not by upsell avoidance.
Monitor, re-score, decide
Serial panels and continuous wearable data track the rate of change, not just a single value. That trajectory is what tells us whether to hold the current protocol, adjust it, or add the next variable.
Confidence intervals, not confidence tricks.
Illustrative example only — not an actual patient result. Shaded band represents the 95% confidence interval narrowing as serial panels accumulate; the score itself is the Regenerative Velocity Index (rate of change), not a static value.
Two numbers matter more than the score itself: the confidence interval around it, and the velocity of change between draws. A score can look good and still not be moving — or move fast enough that the interval collapses and we can act on it early.
This is why the report you get back isn’t a pass/fail grade. It’s an evidence state: high-confidence and actionable, borderline and worth another draw, or insufficient and not yet worth treating. Every protocol recommendation on this site’s application forms is gated by that state.
Precise specification. Certified sourcing.
We are not a compounding pharmacy, and we do not manufacture or administer therapies. The consultation and the Close Regenerative Index determine exactly what a protocol requires — active, dose, and delivery format — and we facilitate sourcing, logistics, and verification through independent ISO- and USP<797>-certified partner facilities.
Exact specification
The CRI defines active, dose, and delivery format from your biomarker data before any sourcing conversation starts — nothing defaulted, nothing assumed.
ISO & USP<797> sourcing
We source and verify exclusively through independent ISO- and USP<797>-certified compounding and testing facilities, audited on GMPc provenance, HPLC verification, and sterility standards.
Verified logistics
Partner facilities maintain tiered cold-chain storage matched to compound stability — refrigerated through cryogenic — audited as part of our sourcing verification, not run in-house.
Physician-directed handoff
Your physician and care team coordinate specification, sourcing, and delivery timing end-to-end, then hand off compounding and administration to the appropriately licensed party.
Essential, longevity, performance, cognitive, hormonal — the same discipline, every category.
No line-item menu here. These are the capability categories the CRI selects from once your data qualifies you — each one indication-gated, not a walk-in add-on.
Essential IVs
Physician-curated protocols for hydration, micronutrient repletion, and acute recovery — the entry tier, still guided by physician review at every session.
Longevity & Regenerative
NAD⁺ pathway support (NAD⁺, NMN, dual-precursor protocols), mitochondrial and cellular-repair stacks selected against organic acid and metabolic panel data.
Performance & Recovery
Pre- and post-training protocols targeting vascular, connective-tissue, and energy-substrate pathways for athletes and high physical-output patients.
Nootropics & Cognitive
BDNF/TrkB-pathway and neurological-cofactor protocols for cognitive fatigue, burnout, and executive-function complaints, gated by cognitive and neurotransmitter panel data.
TRT & Hormonal Optimisation
Physician-directed testosterone and adjunct hormonal protocols on a mandatory 90-day retest cycle. Panel-gated; not a walk-in option.
Custom Peptide Pens
Subcutaneous pen protocols for repair, immune, mitochondrial, and metabolic indications — dosing determined from bloodwork and continuous wearable data, sourced through certified partner facilities.
Supplement & Nutraceutical Protocols
We don’t stock generic retail-form supplements. Where oral support is indicated, we specify a custom blend matched to your panel and source it through a certified compounding partner — flagged clearly where an agent is outside our core formulary.
Diagnostics First
Foundation panels, organic acid analysis, neurotransmitter and epigenetic testing, and wearable integration — the inputs every protocol above is built from.
Monitoring & Re-Scoring
Every protocol carries a built-in re-test cycle. The plan is only ever as complex as the last confirmed result justifies.
Two ways in — pick the one that matches what you already have.
If you have wearable data or recent bloodwork, apply directly. If you don’t yet, start with the CRI calculator — it works with whatever you have and tells you what to get next.
- Minimum 30 continuous days of wearable data (HRV, sleep, ANS) — or a recent blood panel (within 3 months, subject to clinical review).
- Applications submitted without supporting data are not reviewed.
- Acceptance is not guaranteed — the same evidence gate applies to every applicant.
