Dr. Ross Grant’s research on NAD+ highlights the significant role this molecule plays in cellular health, energy production, and DNA repair. Here are key insights into the different dosages and their effects.
NAD+ Dosage Guidelines #
| Condition | Dose | Infusion Rate | Duration |
|---|---|---|---|
| General Wellness | 250mg | Slow (2.5–3 hrs) | Monthly maintenance |
| Energy/Anti-Aging | 500mg | Slow (3–4 hrs) | Weekly x4, then monthly |
| Neurological/Addiction | 750–1000mg | Slow (4–5 hrs) | Daily x 5–10 days |
Why Slow Infusion Matters #
Dr. Grant’s research suggests slow infusion over 2.5 to 5 hours is more beneficial for intracellular uptake because:
- Allows NAD+ to cross cell membranes before being metabolized to AMP
- Reduces side effects (flushing, nausea, chest tightness)
- Ensures maximum sirtuin activation and DNA repair
Why Fast Push Is Suboptimal #
- Rapid NAD+ influx overwhelms cell transporters
- Excess is rapidly metabolized to AMP rather than entering cells
- AMP does not provide the same mitochondrial benefits
