Here are three simple and accessible blood tests that can indirectly provide insights into NAD+ status, along with interpretation strategies for NAD-related findings.

1. Uric Acid #

Why it matters: Elevated uric acid can indicate impaired NAD+ metabolism and mitochondrial dysfunction. High uric acid correlates with reduced NAMPT activity, the rate-limiting enzyme in the NAD+ salvage pathway.

Interpretation: Uric acid above 6 mg/dL in women or 7 mg/dL in men may suggest NAD+ depletion is contributing to metabolic dysfunction. Post-NAD+ therapy, declining uric acid suggests improved salvage pathway efficiency.

2. hs-CRP (High-Sensitivity C-Reactive Protein) #

Why it matters: Chronic inflammation directly depletes NAD+ by activating PARP enzymes. hs-CRP is a sensitive marker of systemic inflammation and an indirect indicator of NAD+ demand.

Interpretation: hs-CRP above 1 mg/L suggests significant inflammatory NAD+ drain. Successful NAD+ replenishment typically reduces hs-CRP by 30–50% over 3 months of consistent therapy.

3. Lactate-to-Pyruvate Ratio #

Why it matters: This ratio directly reflects the NAD+/NADH balance in cells. An elevated ratio (above 25:1) indicates a shift toward NADH accumulation and impaired mitochondrial function — a hallmark of NAD+ deficiency.

Interpretation: A normalizing lactate-to-pyruvate ratio following NAD+ therapy confirms successful intracellular NAD+ restoration and improved mitochondrial function.

At DripDok, we take pride in offering evidence-based protocols and solutions that prioritize patient safety and outcomes above all else. By consistently backing our results with objective evidence and measurable improvements, we foster trust and transparency with our patients.